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Competitive APIs

Fluticasone Propionate 80474-14-2

Fluticasone propionate belongs to a class of drugs known as corticosteroids, specifically glucocorticoids, which are hormones that predominantly affect the metabolism of carbohydrates and, to a lesser extent, fat and protein. It is used to treat asthma, allergic rhinitis, nasal polyps, various skin disorders and Crohn's disease and ulcerative colitis. It is also used to treat eosinophilic esophagitis.

Fluticasone propionate is a white powder with a molecular weight of 500.6, and the empirical formula is C25H31F3O5S. It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol.

Fluticasone Propionate 80474-14-2
Fluticasone Propionate 80474-14-2
Appearance:white powder
Cas No:80474-14-2
EINECS:NA
Formula:C25H31F3O5S
Molecular Weight:500.57
Melting Point:275 °C
Boiling Point: 568.3 °C
Flash Point: 297.5 °C
Usage:anti-asthmatics
Testing Items
Standards:EP6.0
Appearance
A white or almost white crystalline powder
Identification
Should conform
Residual solvent
Acetone: NMT1.0%
Specefic Rotation
+32° ~ 36°
Water
NMT0.2%
Related Substances(HPLC)
Impurity D,G: NMT0.3%
Impurity A,B,C,E,F,H,I: NMT0.2%
Impurity RRT1.23: NMT0.2%
Any other impurity: NMT0.1%
Total impurity:NMT1.2%
Assay
97.0%~102.0%

GMP for Fluticasone propionate is not available yet, DMF for Fluticasone propionate is under Preparation.
 
Disclaimer:Those products (Fluticasone Propionate 80474-14-2) patented are for lab analytical & research purposes only.