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1146963-51-0 ABT-199 J147

1146963-51-0 ABT-199 J147

J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging.

The approach that lead to development of the J147 drug was to screen candidate molecules for anti-aging effects, instead of targeting the amyloid plaques. It is contrary to the most of other approaches to develop drugs against the Alzheimer's disease that target the plaque deposits in the brain.

The J147 drug is also reported to address other biological aging factors, such as preventing the leakage of blood from microvessels in mice brains.[5] The development of J147 follows the chemical pharmacological way, contrary to biological ways that exploit e.g. use of bacteriophages.

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